Our Experience

 

  1. Seligson DB, Horvath S, Shi T, Yu H, Tze S, Grunstein M, Kurdistani SK. Global histone modification patterns predict risk of prostate cancer recurrence. Nature. 2005; 435(7046): 1262-6
  2. Sawai, H, Okada, Y, Kazanjian K, Kim J, Hasan S, Hines O, Reber H, Hoon D and Eibl G The G691S RET Polymorphism Increases Glial Cell Line-Derived Neurotrophic Factor-Induced Pancreatic Cancer Cell Invasion by Amplifying Mitogen-Activated Protein Kinase Signaling. Cancer Res. 2005 65 (24):11536-44.
  3. Christiansen JJ, Rajasekaran, SA, Inge L, Cheng L, Anilkuman G, Bander N, Rajasekaran AK.
    N-glycosylation and microtubule integrity are involved in apical targeting of prostate-specific membrane antigen: implications for immunotherapy. Mol. Cancer Ther. 2005; 4:704-14.
  4. Thomas GV, Tran C, Mellinghoff IK, Welsbie DS, Chan E, Fueger B, Czernin J, Sawyers CL. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med. 2006; 12(1); 122-7.
  5. Dohadwala M, Yang S, Luo J, Sharma S, Batra R, Huang M, Lin Y, Goodglick L, Krysan K, Fishbein M, Hong L, Lai C, Cameron R, Gemmill R, Drabkin H, Dubinett S. Cyclooxygenase-2–Dependent Regulation of E-Cadherin: Prostaglandin E2 Induces Transcriptional Repressors ZEB1 and Snail in Non–Small Cell Lung Cancer. Cancer Res 2006; 66, 5338-5345.
  6. Hoyer K, Pang M, Gui D, Shintaku I, Kuwabara I, Liu F, Said J, Baum L, and Teitell M. An Anti-Apoptotic Role for Galectin-3 in Diffuse Large B-Cell Lymphomas. Am J Pathol 2004, 164:893–902.
  7. Wadehra M, Natarajan S, Seligson DB, Williams CJ, Hummer AJ, Hedvat C, Braun J, Soslow RA. Expression of epithelial membrane protein-2 is associated with endometrial adenocarcinoma of unfavorable outcome. Cancer 2006; 107(1); 90-8.
  8. Christiansen J., S.A. Rajasekaran, P. Moy, A. Butch, L. Goodglick, N. Bander, R.Reiter, Z. Gu, and A.K. Rajasekaran (2003). Polarity of Prostate specific membrane antigen, Prostate stem cell antigen, and prostate specific antigen in MDCK cells and in prostate tissue. Prostate, 2003 55: 9-19.
  9. Kim G., S.A. Rajasekaran, G. Thomas, E. Rosen, E. Landaw, P. Shintaku, C. Lassman, J. Said, and A K. Rajasekaran (2005). Renal clear-cell carcinoma: an ultrastructural study on the junctional complexes. Histology and Histopath. 20:35-44.
  10. Christiansen J.J., S.A. Rajasekaran, L. Inge, L. Chang, G. Anilkumar, N. Bander, and A.K. Rajasekaran (2005). N-glycosylation and microtubule integrity are involved in apical targeting of prostate specific membrane antigen; implication for immunotherapy. Mol. Cancer.Ther. 4:704-714 (Cover Article).
  11. Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood. 2005 Oct 15;106(8):2884-9.
  12. Miller LS, Sorensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE, Chung W, Starner TD, Kim J, Sieling PA, Ganz T, Modlin RL. TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol. 2005 May 15;174(10):6137-43.
  13. Sorensen OE, Thapa DR, Rosenthal A, Liu L, Roberts AA, Ganz T. Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol. 2005 Apr 15;174(8):4870-9.
  14. Sawai H, Okada Y, Kazanjian K, Kim J, Hasan S, Hines OJ, Reber HA, Hoon DSB, Eibl G. The G691S RET polymorphism increases GDNF-induced pancreatic cancer cell invasion by amplifying MAPK signaling. Cancer Res 2005;65(24):11536-11544
  15. Eibl G, Reber HA. A xenograft nude mouse model for perineural invasion and recurrence in pancreatic cancer. Pancreas 2005;31(3):258-262
  16. Guha S*, Eibl G*, Kisfalvi K, Fan RS, Burdick M, Reber HA, Hines OJ, Strieter R, Rozengurt E. Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res 2005;65(7):2738-2745 (*dual first authorship)
  17. Miller LS, O'Connell RM, Gutierrez MA, Pietras EM, Shahangian A, Gross CE., Thirumala, A, Cheung AL., Genhong Cheng, Robert L. Modlin. MyD88 Mediates Neutrophil Recruitment Initiated by IL-1R but Not TLR2 Activation in Immunity against Staphylococcus aureus. Immunity. 2006. 24(1):79-91.
  18. Miller LS., Sørensen OE., Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE., Chung W, Starner TD, Kim J, Sieling PA., Ganz T ,. Modlin RL. TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J. Immunology. 2005. 174(10):6137-43
  19. Schumacher LY, Vo DD, Garban HJ, Comin-Anduix B, Owens SK, Dissette VB, Glaspy JA , McBride WH, Bonavida B, Economou JS, Ribas A. Immunosensitization of tumor cells to dendritic cell-activated immune responses with the proteasome inhibitor bortezomib (PS-341, Velcade). J Immunol. 2006; 176(8); 4757-65.
  20. Ng PP, Helguera G, Daniels TR, Lomas SZ, Rodriguez JA, Schiller G, Bonavida B, Morrison SL, Penichet ML. Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor.Blood. 2006 Jun 27; [Epub ahead of print].
  21. Huang T, Wei B, Velazquez P, Borneman J, Braun J. Commensal microbiota alter the abundance and TCR responsiveness of splenic naïve CD4+ T lymphocytes. Clin Immunol. 2005; 117(3); 221-30.
  22. Kassan H, Cohavy O, Rosenbaum JT, Braun J, Gordon LK. Uveitis seroreactivity to candidate pANCA antigens: mycobacterial HupB and histone H1(69-171). Ocul Immunol Inflamm. 2005; 13(2-3); 191-8.
  23. Braun J, Targan SR. Multiparameter analysis of immunogenetic mechanisms in clinical diagnosis and management of inflammatory bowel disease. Adv Exp Med Biol. 2006; 579; 209-18.
  24. Iltanen S, Tervo L, Halttunen T, Wei B, Braun J, Rantala I, Honkanen T, Kronenberg M, Cheroutre H, Turovskaya O, Autio V, Ashorn M. Elevated serum anti-I2 and anti-OmpW antibody levels in children with IBD. Inflamm Bowel Dis. 2006; 12(5); 389-94.
  25. Wadehra M, Natarajan S, Seligson DB, Williams CJ, Hummer AJ, Hedvat C, Braun J, Soslow RA. Expression of epithelial membrane protein-2 is associated with endometrial adenocarcinoma of unfavorable outcome. Cancer. 2006; 107(1); 90-8.
  26. Wadehra M, Dayal M, Mainigi M, Ord T, Iyer R, Braun J, Williams CJ. Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse. Dev Biol. 2006; 292(2); 430-41.
  27. Lee FY, Kast-Woelbern HR, Chang J, Luo G, Jones SA, Fishbein MC, Edwards PA . Alpha-crystallin is a target gene of the farnesoid X-activated receptor in human livers. J Biol Chem. 2005; 280(36); 31792-800.
  28. Guha S, Eibl G , Kisfalvi K, Fan RS, Burdick M, Reber H, Hines OJ, Strieter R, Rozengurt E . Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res. 2005; 65(7); 2738-45.
  29. Dohadwala M, Yang SC, Luo J, Sharma S, Batra RK , Huang M, Lin Y, Goodglick L , Krysan K, Fishbein MC, Hong L, Lai C, Cameron RB, Gemmill RM, Drabkin HA, Dubinett SM . Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. Cancer Res. 2006; 66(10); 5338-45
  30. Seligson D, Horvath S, Huerta-Yepez S, Hanna S, Garban H, Roberts A, Shi T, Liu X, Chia D, Goodglick L , Bonavida B. Expression of transcription factor Yin Yang 1 in prostate cancer. Int J Oncol. 2005; 27(1); 131-41.
  31. Shen D, Chang HR , Chen Z, He J, Lonsberry V, Elshimali Y, Chia D, Seligson D, Goodglick L , Nelson SF , Gornbein JA. Loss of annexin A1 expression in human breast cancer detected by multiple high-throughput analyses. Biochem Biophys Res Commun. 2005; 326(1); 218-27.
  32. Hoang B, Zhu L, Shi Y, Frost P, Yan H, Sharma S, Sharma S, Goodglick L , Dubinett S, Lichtenstein A . Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance. Blood. 2006; 107(11); 4484-90.
  33. Weinberg OK, Marquez-Garban DC, Fishbein MC, Goodglick L , Garban HJ, Dubinett SM , Pietras RJ . Aromatase inhibitors in human lung cancer therapy. Cancer Res. 2005; 65(24); 11287-91.
  34. Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL . TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med. 2005; 11(6); 653-60.
  35. Chadburn A, Hyjek E, Mathew S, Cesarman E, Said J, Knowles DM. KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma. Am J Surg Pathol. 2004; 28(11); 1401-16.
  36. Gery S, Xie D, Yin D, Gabra H, Miller C, Wang H, Scott D, Yi WS, Popoviciu ML, Said JW, Koeffler HP. Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells. Clin Cancer Res. 2005; 11(20); 7243-54.
  37. Han KR, Seligson DB, Liu X, Horvath S, Shintaku PI, Thomas GV, Said JW, Reiter RE. Prostate stem cell antigen expression is associated with gleason score, seminal vesicle invasion and capsular invasion in prostate cancer. J Urol. 2004; 171(3); 1117-21.
  38. Kumagai T, Ikezoe T, Gui D, O'Kelly J, Tong XJ, Cohen FJ, Said JW, Koeffler HP. RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide. Clin Cancer Res. 2004; 10(4); 1508-20.
  39. Lam JS, Shvarts O, Said JW, Pantuck AJ , Seligson DB, Aldridge ME, Bui MH, Liu X, Horvath S, Figlin RA, Belldegrun AS . Clinicopathologic and molecular correlations of necrosis in the primary tumor of patients with renal cell carcinoma. Cancer. 2005; 103(12); 2517-25.
  40. Thomas GV, Tran C,Mellinghoff IK, Welsbie DS, Chan E, Fueger B, Czernin J, Sawyers CL. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med. 2006; 12(1); 122-7.
  41. Li, H.H., Yu, W.H., Rozengurt, N., Zhao H.Z., Anagnostaeras S, Fanselow M., Suzuki, H, Vanier M., Neufield E.F. (1999). Mouse Model of Sanfilippo Syndrome Type-B Produced Targeted Disruption of the gGene Encoding alpha-N-acetyl Glucosaminidase. Proceedings of the National Academy of Sciences USA. 96: 14505-14510.
  42. Whang, Y.E., Tran, C., Henderson, C., Syljuasen, R.G., Rozengurt, N., McBride, .H., and Sawyers, C.L. (2000) cAbl is Required for Development and Optimal Cell Proliferation in the Context of p53 Deficiency. Proceedings of the National Academy of Sciences USA97: 5486-5491
  43. Neusch C., N. Rozengurt, Jacobs R E, Lester H.A., and Kofuji P. (2001). Kir4.1Potassium Channel Subunit Is Crucial for Oligodendrocyte Development and In Vivo Myelination. Journal of Neuroscience 21: (15) 5429-38.
  44. Iyer RK, Yoo PK, Kern RM, Rozengurt N, Tsoa R, O’Brien WE, Yu H, Grody WW, Cederbaum SD. (2002). A Mouse Model for Human Arginase Deficiency. Molecular Cell Biology 22: 4491-98.
  45. Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E. (2002). Expression of Bitter Taste Receptors of the T2R Family in the Gastrointestinal Tract and in Enteroendocrine STC-1 cells. Proceedings of the National Academy of Science 19;99: 2392-97.
  46. Rozengurt N, Lopez I., Chiu C, Kofuji P., Lester H. and Neusch C. (2003) Time Course of Inner Ear Degeneration and Deafness in Mice Lacking the Kir4.1 Potassium Channel Subunit. Hearing Research. 177:71-80.
  47. Giese, MJ, Rayner , SA, Fardin, B, Sumner, HA, Rozengurt, N, Mondino BJ, Gordon, LK.(2003) Mitigation of Neutrophil Infiltration in a Rat Model of Active, Early Staphylococcus aureus Endophthalmitis. Investigative Ophthalmology Vision Sciences 44: 3077-3082.
  48. Wang S; Gao J; Lei Q; Rozengurt N; Pritchard C; Jiao J; Thomas, G; Li, G.; Roy-Burman, P; Nelson P; Liu X; and Wu H (2003). Prostate-Specific Deletion of the Murine Pten Tumor Suppressor Gene Leads to Metastatic Prostate Cancer. Cancer Cell 2003 4 :209-21.
  49. Shappell SB, Thomas GV, Roberts RL, Herbert R, Ittmann MM, Rubin MA, Humphrey PA, Sundberg JP, Rozengurt N, Barrios R, Ward JM, Cardiff RD (2004). Prostate Pathology of Genetically Engineered Mice: Definitions and Classification. The Consensus Report from the Bar Harbor Meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee. Cancer Research 64:2270-305.
  50. Nikitin AY, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, Fraire AE, Gabrielson EW, Gunning WT, Haines DC, Kaufman MH, Linnoila RI, Maronpot RR, Rabson AS, Reddick RL, Rehm S, Rozengurt N, Schuller HM, Shmidt EN, Travis WD, Ward JM, Jacks T. (2004). Classification of Proliferative Pulmonary Lesions of the Mouse: Recommendations of the Mouse Models of Human Cancers Consortium. Cancer Research 64:2307-16.
  51. Waldherr C., Mellinghoff IK, Tran C, Halpern BS, Rozengurt N, Safaei A., Weber WA, Stout D, Satyamurthy N, Barrio J, Phelps ME, Silverman DH, Sawyers CL, Czernin J. (2005). Monitoring Antiproliferative Responses to Kinase Inhibitor Therapy in Mice with 3'-Deoxy-3'-18F-Fluorothymidine PET. Journal of NuclearMedicine 46:114-120.
  52. Freeman D, Lesche R, Kertesz N, Gao J, Groszer M, Martinbez-Diaz H, Rozengurt N, Thomas G, Cardiff R, Liu X, Wu H.(2006) Genetic Background. Controls Tumor Development in Pten Deficient Mice. Cancer Research 66: 6492-6.
  53. Rozengurt N, Wu SV, Chen MC, Huang C, Sternini C, Rozengurt E. (2006). Co-localization of the a Subunit of Gustducin with PYY and GLP-1 in L Cells of Human Colon. American Journal of Physiology Gastroenterology Liver Physiology 291:G792-G802.
  54. Lin JA., Watanabe J, Rozengurt N, Narasimha A, Martin MG., Braun J, Langenbach R,. Reddy ST. (2007) Atherogenic Diet Causes Lethal Ileo-ceco-colitis in Cyclooxygenase-2 Deficient Mice. Prostaglandins 84: 98-107.
  55. Kimura T, Koya RC, Anselmi L, Sternini C, Wang HJ, Comin-Anduix B, Prins RM, Faure-Kumar E, Rozengurt N, Cui Y, Kasahara N, Stripecke R. (2007). Molecular Therapy. 15:1390-9.