Goals & Mission

 

The High-Throughput (HT) Clinical Proteomics laboratory was established specifically to assist those engaged in clinical research at UCLA in the analysis of protein profiles of large number of patient samples. We are geared to use robotic methods for the extraction of intact proteins and peptides from clinical isolates followed by analyses of protein patterns that provide diagnostic information on groupings in the patient population. We do not identify as many proteins as possible in these samples; we isolate and ID only those determined to be of clinical significance. Our approach is to validate these biomarker candidates in a relevant number of patient samples before identification. While we usually study intact masses of proteins and peptides, we can also analyze those subjected to protease digestion. The facility is available for the analysis of dozens to hundreds of samples.