CD1 represents three distinct molecules designated CD1a, CD1b and CD1c which are predominantly expressed by cortical thymocytes and interdigitating cells. Langerhans' cells are CD1a positive. Mantle cells, cord blood, and some of the peripheral blood and spleen B cells are CD1c positive. Follicular denditic cells, monocytes/macrophages and all postthymic neoplasms are CD1 negative.
CD2
This protein is a pan T cell marker and is one of the earliest T cell-associated antigens; it appears after CD7 but before CD1. CD2 is a ligand for CD58 (LFA-3, receptor for sheep erythrocytes ) and CD59. It is expressed by immature and mature T cells and by natural killer (NK) cells. This molecule is an excellent T cell marker for the evaluation of lymphoid malignancies. CD2 expression has been also reported in some cases of AML.125
SELECTED REFERENCES
Cattorettti G, Berti E, Mancuso A, et al: A MCH class I related family of antigens with widespread distribution on resting and activated cells. In: Leukocye tryping III. White cell differentiation antigens. McMichael AJ, Beverley PCL, Cobbold S, et al (eds), Oxford, Oxford University Press, 1987 P 89.
Small NT, Knowles RW, Keever C, et al: M241 (CD1) expression on B lymphocytes. J Immunol 138: 2864, 1987
Porcelli S, Mouta CT, Brenner MB: CD16 restricts the response of human CD48 T-lymphocytes to a microbial antigen. Nature 360:593, 1992.
Orazi A, Cattoretti G, Polli N, et. al:. Distinct morphophenotypic features of chronic B-cell leukaemias identified with CD1c and CD23 antibodies. Eur J Haematol 47: 28, 1992
McMichael AJ, Gotch FM: T cell antigens: new and previously defined clusters. In: Leukocye tryping III. White cell differentiation antigens. McMichael AJ, Beverley PCL, Cobbold S, et al (eds), Oxford, Oxford University Press, 1987 P 31
Mirro J, Antouin GR, Zipf TF, et al: The E-resette associated antigen of T cells can be identified on blasts from patients with acute myeloblastic leukemi. Blood 65: 363, 1985
Potocnik AJ, Menningers H, and Yang SY, et. al: Expression of the CD2 Activation Epitope TII-3 (CD2R) on T cells in rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, ankkylosing spondylitis and lyme disease: Phenotypic and Functional Analysis. Scand J Immunol 34: 351, 1991
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