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Four hours weekly - Lecture, 1 hour on molecular basis of a disease pertaining to a particular organ or disease; 1 hour student presentations directly following lecture - 2 students will present papers related to lecture; 2 hours lab pertaining to lecture topic - Students sit down at multi-head microscopes and visualize diagnostic parameters of disease. Letter grading. |
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Lecture, three hours; laboratory, one hour. Preparation: knowledge of basic immunology. New developments in organ transplantation, updates on basic science of immune mechanisms, integration of basic science principles with clinical practice. Letter grading. |
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Lecture, two hours; discussion, one hour; laboratory, one hour. Requisite: Microbiology M261. Advanced information for graduate and advanced undergraduate students regarding immune system anatomy, lymphocytic development, acute and chronic inflammation, hypersensitivity, and autoimmunity. Letter grading. |
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Formerly numbered M294.) Lecture, three hours. Requisites: Biol Ch. 253, 248, CM267A & B (current first two terms of ACCESS curriculum), or Instructor’s Approval. Fundamental biological, genetic, and molecular process involved in genesis and growth of cancer cells and diagnosis, characterization, and treatment of cancer. Letter grading. |
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Preparation: one course each in molecular biology, cell biology, and biological chemistry. Designed for graduate experimental pathology students. Current research in disease mechanisms, with strong emphasis on experimental approach in pathology. Topics include genetic and metabolic disorders, thyroid disease, immunology, atherosclerosis, infectious diseases, and Alzheimer's disease. /SU or letter grading. |
Each student will choose one paper from a list of recent publications that highlight the role of glycosylation in immune development or immune interactions. This will include glycosylation of proteins and lipids made by cells of the immune system, as well as glycans on the surface of pathogens, and will focus on biologic processes such as immune organogenesis, leukocyte trafficking in inflammation, immune cell signaling, host-pathogen interactions, and recognition of carbohydrate antigens by the innate immune system. Each student will make a critical presentation of the work in the paper, including a 15-20 minute introduction to the background of the problem prior to describing the experiments in the paper that address the problem. The final project will be a 2-3 pg. letter of intent to a hypothetical funding agency, outlining a hypothetical research project that addresses a significant question in Glycoimmunology; this project must be distinct from the topic of the paper presented by the student. |
Instructors: Ayyappan K Rajasekaran and Sigrid A Rajasekaran
About 90% of human cancers are derived from epithelial cells. It is believed that when the epithelial cells become metastatic cancer cells they lose their morphology and attain mesenchymal phenotype. This conversion of phenotype is referred to as epithelial to mesenchymal transition (EMT). It has been widely accepted that EMT is a prerequisite for cancer metastasis. However, recent studies argue whether EMT is required for cancer metastasis. In this class, the students will be divided into two groups. One group of students will receive papers that support EMT whereas the second group will receive papers that disagree with EMT being required as a prerequisite for metastasis. Two students from each of these groups will present their papers (one hour each) and should discuss why their case is right. This will be a fun class to learn about cancer metastasis.
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